缬沙坦联合己酮可可碱治疗糖尿病肾病效果分析

Analysis of effect of valsartan combined with pentoxifylline on diabetic nephropathy

目的:探究缬沙坦联合己酮可可碱在治疗临床期糖尿病肾病及视网膜病变的疗效。方法:随机取36例(72眼)2型糖尿病并发糖尿病性视网膜病及肾病患者,随机分为观察组与对照组,各18例。对照组采用缬沙坦治疗,观察组在对照组基础上加服PTX治疗。对两组治疗有效率及相关指标进行对比。结果:对照组治疗有效率为66.67%,观察组治疗有效率94.44%,两组对比差异有统计学意义(P<0.05);在血压、肾功能等指标方面综合对比,观察组改善幅度明显优于对照组,差异有统计学意义(P<0.05)。结论:缬沙坦联合PTX对于治疗临床期糖尿病肾病及视网膜病变相比于单用缬沙坦的治疗方案更具优势,能更加有效的改善肾功能和保护眼底。

Objective：To investigate the efficacy of valsartan combined with pentoxifylline in the treatment of diabetic nephropathy and retinopathy. Methods：30 patients（60 eyes） with type 2 diabetes mellitus complicated with diabetic retinopathy and nephropathy were randomly divided into observation group and control group. The control group was treated with valsartan and the observation group was treated with PTX on the control group. The two groups were compared with the effective rate and related indexes. Results：The effective rate was 66.67% in the control group and 93.33% in the observation group. There was significant difference between the two groups（P〈0.05）. The improvement of the blood pressure and renal function was significant Compared with the control group, the difference was statistically significant（P〈0.05）. Conclusion：Valsartan combined with PTX is more effective in the treatment of diabetic nephropathy and retinopathy than in the treatment of valsartan alone, which can improve the renal function and protect the fundus more effectively.