四妙散的临床运用及作用机制

Clinical application and mechanism of Four Wonderful Herbs powder

四妙散乃传统经方,是清热燥湿方中的一个代表方剂,主治湿热下注之症。其临床运用较为广泛,可治疗多种疾病,其常用于治疗痛风、高尿酸血症,也可用于关节炎、糖耐量异常、宫颈炎、湿疹等疾病。现代药理对其作用机制深入研究,从单药及复方层面进行探讨,发现其通过清热利湿,参与体内炎症因子的调控,参与氧化应激反应,缓解胰岛素抵抗,并可以促进尿酸排泄,减少尿酸沉积和重吸收。

Four Wonderful Herbs powder is the traditional decoction,which is a representative prescription of clearing heat and drying dampness,the attending of treating dampness-heat pouring down.Its clinical application is widely,it can treat various diseases.Four Wonderful Herbs powder is often used to treat gout,hyperuricemia,arthritis,abnormal glucose tolerance,cervicitis,eczema and other diseases.Modern pharmacological research on its mechanism deeply,from the aspect of single drug and compound were discussed.It found that the mechanism mainly through clearing heat and draining dampness,participate in the regulation of inflammation in the body involved in oxidative stress reaction,relieve insulin resistance,and can promote the uric acid excretion,reduce uric acid deposition and reabsorption.