ROC曲线分析人附睾蛋白4在卵巢癌的诊断价值

Analysis of significance of human epididymal protein 4 in diagnosis of ovarian cancer by ROC curve

目的通过ROC曲线分析人附睾蛋白4(human epididymal protein 4,HE4)在卵巢癌的诊断价值。方法将107例卵巢疾病患者分为正常对照组(21例)、良性卵巢肿瘤组(20例)、Ⅰ-Ⅱ期卵巢癌组(14例)、Ⅲ期卵巢癌组(30例)、Ⅳ期卵巢癌组(22例)。分别对5组受试患者进行血清HE4水平测定和影像学检测,在灵敏性和特异性方面比较两者在卵巢癌诊断的价值;对各组患者血清HE4水平进行ROC曲线分析,评价血清HE4在卵巢癌诊断方面的价值。结果血清HE4水平检测在灵敏性上明显高于影像学检查,差异有统计学意义(P<0.05),而特异性差异无统计学意义(P>0.05),且血清HE4水平随着癌症恶性程度的增加而升高;ROC曲线线下面积AUG为0.912,具有较高的诊断价值。结论血清HE4水平检测在灵敏性上明显高于影像学检查,并且具有较好的特异性,可作为卵巢癌辅助检查手段,具有较高的临床诊断价值。

Objective To analyze the significance of human epididymal protein 4（HE4）in diagnosis of ovarian cancer by ROC curve. Methods A total of 107 patients with ovarian diseases were divided into normal control（21 cases）, benign ovarian tumor（20 cases）as well as ovarian cancer of stagesⅠ- Ⅱ（14 cases）, Ⅲ（30 cases）and IV（22 cases）groups,then determined for serum HE4 level and subjected to imaging examination. The two methods were evaluated for significance in diagnosis of ovarian cancer in terms of sensitivity and specificity. However, the serum HE4 levels in various groups were analyzed by ROC curve to evaluate such significance of HE4. Results The sensitivity of serum HE4 level was significantly higher than that of imaging examination（P〈0. 05）, while the specificity of the former showed no significant difference with that of the latter（P〉0. 05）. The serum HE4 level increased with the increasing malignancy.The AUG of ROC curve was 0. 912, indicating an important significance in diagnosis of ovarian cancer. Conclusion Serum HE4 level showed higher sensitivity than imaging examination, as well as high specificity, which might be used for assistant diagnosis of ovarian cancer, and of an important significance in diagnosis of ovarian cancer.