地特胰岛素联合阿卡波糖治疗2型糖尿病34例有效性观察

Effective observation of insulin determir combined with acarbose in treatment of 34 cases of type 2 diabetes mellitus

目的观察起始应用地特胰岛素治疗2型糖尿病的有效性、安全性。方法选取2型糖尿病患者68例,随机分为地特胰岛素联合阿卡波糖组(治疗组)及精蛋白生物合成人胰岛素(30R)组(对照组),比较2组治疗前后空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹C肽、餐后2 h C肽、每日胰岛素用量、体质量指数、低血糖事件发生情况。结果治疗后2组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均显著低于治疗前,治疗组餐后2 h C肽水平明显高于治疗前,差异有统计学意义(P<0.05)。治疗后治疗组低血糖发生率和体质量指数显著低于对照组,差异有统计学意义(P<0.05);而2组间空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹C肽、餐后2 h C肽水平和结束时每日胰岛素用量差异均无统计学意义(P>0.05)。结论地特胰岛素联合阿卡波糖降糖效果显著,不会增加患者体质量及低血糖事件发生率,并能够促进胰岛功能修复。

Objective To observe the efficacy and safety of initiating insulin therapy with insulin detemir in type 2 diabetes mellitus（T2DM）.Methods Sixty-eight subjects with T2DM were randomly divided into two groups.Fasting blood glucose,postprandial 2 h blood glucose, glycosylated hemoglobin,fasting C peptide,postprandial 2 hC peptide,daily insulin dosage, body mass index,and hypoglycemic events were compared between the 2 groups before and after treatment.Results After treatment,fasting blood glucose,postprandial 2 h blood glucose and glycosylated hemoglobin levels of the 2 groups were significantly lower than those before treatment.The level of 2 hC peptide in the treatment group was significantly higher than that before the treatment,the difference was statistically significant（P〈0.05）.After treatment,the incidence of hypoglycemia in the treatment group was significantly lower than that in the control group,and the body mass index of the treatment group was significantly lower than that of the control group,the difference was statistically significant （P0.05）.Conclusion Insulin detemir combined with acarbose hypoglycemic will not increase the body weight and the incidence of hypoglycemia,and can promote the repair of islet function.