慢性阻塞性肺疾病患者认知功能状况及影响因素分析

Analysis of Cognitive Function and Its Influencing Factors in Patients with Chronic Obstructive Pulmonary Disease

目的了解慢性阻塞性肺疾病住院患者认知功能情况,分析影响慢性阻塞性肺疾病患者认知功能的因素。方法选取2014年10月至2015年9月某三甲医院呼吸内科住院治疗的慢性阻塞性肺疾病患者261例,应用一般情况调查表、MMSE量表、日常生活能力量表(ADL)、汉密顿焦虑量表(HAMA)进行现场问卷调查,收集慢性阻塞性肺疾病患者的一般人口学资料、相关临床资料,采用SPSS17.0统计软件进行统计分析,计数资料采用频数表示,计量资料采用均数±标准差表示,单因素分析采用t检验或方差分析;多因素分析以单因素分析中有统计学意义的各变量为自变量,以MMSE量表得分为因变量进行多元线性回归分析。结果单因素分析结果显示:年龄、城乡、文化程度、月收入、吸烟、锻炼、焦虑、日常生活能力、糖尿病、病程、PaO_2、PaCO_2、FEV1%预计值、MMSE得分差异有统计学意义(P<0.05)。多因素分析结果显示:年龄、吸烟、文化程度、日常生活能力、焦虑、PaO_2水平、FEV1%预测值、Apo E水平是慢性阻塞性肺疾病患者认知功能的影响因素。结论慢性阻塞性肺疾病患者常伴有认知功能障碍。年龄、吸烟、文化程度、日常生活能力、焦虑、PaO_2水平、FEV1%预测值是慢性阻塞性肺疾病患者认知功能的影响因素。

Objective To investigate the cognitive function of inpatients with chronic obstructive pulmonary disease（COPD）, and analyze the factors affecting the cognitive function of COPD patients. Methods 261 hospitalized patients with chronic obstructive pulmonary disease patients From October 2014 to September 2015 in a hospital were selected and investigated using general condition questionnaire, MMSE scale, daily life ability scale（ADL）, Hamilton Anxiety Scale（HAMA） questionnaire survey to collect demographic data. The relevant clinical data, using SPSS17.0 statistical analysis, count data expressed by frequency measurement data expressed by the mean and standard deviation, single factor analysis using the t test or analysis of variance; multi factor analysis to single factor In the element analysis, the statistical variables were independent variables, and the MMSE scale scores were the dependent variables. Results The results of univariate analysis showed that age, urban and rural areas, education level, monthly income, smoking, exercise, anxiety, daily life ability, diabetes, disease duration,PaO2, PaCO2, FEV1% predicted, statistically significant differences in MMSE scores（P 0.05）. Multivariate analysis showed that age, smoking, education, daily the ability of living, anxiety, the level of PaO2, FEV1% predicted, Apo E levels are the influence factors of disease cognitive function in patients with chronic obstructive pulmonary. Conclusion Patients with chronic obstructive pulmonary disease is often accompanied with cognitive dysfunction. Age, smoking, education, daily life ability, anxiety, PaO2 level, FEV1% predictive value of factors influencing the disease cognitive function in patients with chronic obstructive pulmonary.