摘要
脑钠尿肽是主要由心肌细胞分泌的钠尿肽类激素,通常在心肌细胞受到牵拉时产生,具有利钠、利尿、舒张血管、调节血压等功能。临床上BNP是反映心功能的重要指标之一,近年的研究表明,BNP在法医学中对心源性猝死的诊断也具有十分重要的价值。本文综述了BNP的分子结构、表达调控及法医学应用的进展。
Brain natriuretic peptide（BNP）, a natriuretic peptide hormone, is mainly secreted by cardiomyocytes when they are pulled by mechanical force. BNP acts to increase natriuresis and decrease vascular resistance, thereby decreasing blood volume, systemic blood pressure and afterload. It is not only the main indicators of cardiac function which is widely used in clinical, recent studies have also shown that it has a very important value in identifying sudden cardiac death（SCD）. However, the exact expression of the regulation mechanism is still unknown. This paper reviewed the structure, expression of the regulation mechanism of BNP, and the application progress in clinical and forensic.
出处
《中国法医学杂志》
CSCD
2017年第5期472-475,共4页
Chinese Journal of Forensic Medicine
基金
国家自然科学基金资助项目(81273343)
关键词
法医病理学
脑钠尿肽
表达调控
心源性猝死
forensic pathology
brain natriuretic peptide
expression regulation
sudden cardiac death
