针药结合治疗多囊卵巢综合征临床机理研究

Study on Clinical Mechanism of Polycystic Ovarian Syndrome Treated by Acupuncture Combined with Chinese Medicine

目的:探究针刺加中药联合治疗多囊卵巢综合征的临床机理,评价其临床疗效。方法:选取多囊卵巢综合征患者100例,按照随机数字表法分为A、B、C三组,各50例:A组患者予以避孕药炔雌醇环丙孕酮片(达英-35)与促排卵药氯米芬治疗;B组,予以中药治疗;C组予以针刺及中药联合治疗;1个月经周期为1个疗程,共6个疗程;观察治疗前后各组患者月经情况、基础体温、性激素水平、排卵及卵泡等指标。结果:C组治疗总有效率为82%,显著高于对照组(P<0.05)。C组患者月经恢复正常率为100%,显著高于A、B两组(P<0.05)。治疗后,C组基础体温双相率70%显著高于对照组(P<0.05);C组患者基础FSH(14.6±2.9)IU/L、基础E2(53.2±12.4)pg/ml显著高于A、B两组、基础LH(25.4±5.8)IU/L、T(1.0±0.2)μG/L显著低于A、B两组,P<0.05,差异具有统计学意义。结论:针刺和中药结合治疗可通过调理月经、调整双相基础体温、性激素水平、促进排卵来达到治疗多囊卵巢综合征的效果。

This study was aimed to explore the clinical mechanism of combined acupuncture and traditional Chinese medicine （TCM） in the treatment of polycystic ovarian syndrome （PCOS） and to evaluate its clinical curative effect. A total of 100 PCOS patients were randomly divided into three groups, which were group A, B and C, with 50 cases in each group. Group A was treated with ethinyl estradiol and clomiphene. Group B was treated with TCM. Group C was treated with acupuncture combined with TCM. One menstrual cycle was counted as one treatment course. There were a total of 6 treatment courses. Observation was given on menstrual condition of the patient, basal body temperature （BBT）, level of sex hormones, ovulation and follicular before and after treatment. The results showed that the total effective rate of group C was 82%, which was significantly higher than that of the control group （P 〈 0.05）. The normal rate of menstruation recovery of group C was 100%, which was significantly higher than those of group A and B （P 〈 0.05）. After treatment, the biphasic rate of BBT in group C was 70%, which was significantly higher than that of the control group （P 〈 0.05）. The basal FSH （14.6±2.9） IU/L and basal E2 （53.2±12.4） pg/ml of group C were significantly higher than those of group A and B. The basal LH （25.4±5.8） IU/L, T （1.0±0.2） μg/L of group C were significantly lower than those of group A and B （P 〈 0.05）, with statistical significance. It was concluded that acupuncture combined with TCM can be used in the treatment of PCOS by regulating menstruation, adjusting BBT, the level of sex hormone, and promoting ovulation.