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急性冠脉综合征患者IL-12和IL-18血浆水平的临床分析 被引量:1

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摘要 目的探讨急性冠脉综合征患者IL-12和IL-18的血浆水平及其临床意义。方法采用ELISA方法测定急性冠脉综合征(ACS组)和稳定性心绞痛(SAP组)和对照组各70例患者血浆中IL-12和IL-18的水平,并进行比较。结果血浆IL-12水平,ACS组与SAP组均明显高于对照组,差异有统计学意义(P<0.01);血浆IL-18水平,ACS组与SAP组均明显高于对照组,差异有统计学意义(P<0.01);ACS组与SAP组组间比较,血浆IL-12和IL-18水平均有明显差异(P<0.05)。结论 IL-12和IL-18可能参与了冠状动脉粥样硬化病变的病理生理过程,炎性细胞因子水平的增高促进了动脉粥样硬化斑块的不稳定性,可能是促使ACS发生的机制之一。
机构地区 浙江萧山医院
出处 《浙江实用医学》 2017年第4期266-267,共2页 Zhejiang Practical Medicine
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