核仁素在肿瘤发生发展中的作用

Role of nucleolin in the development of tumor

核仁素是细胞核中一种高度保守的多功能蛋白,又称为C23,其在核仁中高度表达并参与多种生物学过程。近几年来,核仁素在肿瘤发生发展中的作用引起人们的广泛关注。核仁素通过作用多种致瘤基因(如Akt)间接或直接影响细胞周期促进细胞增殖,稳定抗凋亡因子IL-9和bcl-2等减少肿瘤细胞凋亡,激活自噬相关途径的基因诱发自噬。在肿瘤进展中,核仁素促进血管生成素的分泌活化内皮细胞(endothelial cells,EC),并且激活趋化因子信号通路提高肿瘤细胞的迁移和侵袭。近来适配子、多肽、免疫剂在核仁素治疗研究中取得了进展。核仁素作为独立预后标志物具有重要的价值。进一步探讨核仁素与肿瘤的关系以及肿瘤发生发展的分子机制,为肿瘤的治疗提供潜在的生物学作用靶点。

Nucleolin is a highly conservative multifunctional protein in the cell nucleus, also called C23, which is rich expressed in the nucleolus and participates in a variety of biological process. In recent years, the role of nucleolin in the development of tumor has received extensive attention. Nucleolin regulates a variety of tumorigenic gene（such as Akt） indirectly or directly influence cell cycle to promote cell proliferation, as well as stabilizes antiapoptotic factor IL-9 and bcl-2 reduced tumor cell apoptosis, activates the related gene in autophagy pathway induced autophagy. In tumor progression, nucleolin promotes the secretion of angiogenin and activates endothelial cells（EC）, meanwhile activates chemokine signaling pathways to increase tumor cell migration and invasion. Recently, in the treatment of nucleolin, aptamer, polypeptide, and immunizing agent make a progress, and as an independent prognostic marker, nucleolin is of great value. Futher exploration on the relationship between nucleolin and tumor, as well as the molecular mechanism of tumor development helps provide potential biological targets for the treatment of tumor.