小檗碱的抗整体小鼠缺氧作用

ANTI-ANOXIC EFFECTS OF BERBER1NE IN INTACT MICE

硫酸小檗碱(Ber)sc能延长常压密闭缺氧小鼠存活时间,但ig无效。Ber sc能对抗异丙肾上腺素或酚妥拉明缩短密闭缺氧小鼠存活时间,延长断头小鼠张口动作持续时间及氰化钾、亚硝酸钠或利多卡因中毒小鼠的存活时间。Ber ig也能延长张口动作持续时间和利多卡因中毒小鼠的存活时间,但作用均较sc弱。Ber的抗缺氧作用表现为减慢机体的耗氧速度及提高异常状态机体对低氧的利用能力。

Berberine sulfate ( Ber ) sc prolonged the survival time of mice under the condition of closed normobaric hypoxia, but Ber ig did not. Ber sc antagonized the effects of decreasing the survival time of mice by ip isoprenaline or phentolamine under the condition of closed normobaric hypoxia, prolonged decapitation-induced gasping duration in mice, and prolonged the survival time in mice poisoned by KCN, NaNO2 or lidocaine. Ber ig prolonged decapitation-induced gasping duration and the survival time in mice poisoned by lidocaine, too. But the effects of Ber ig were not so potent as Ber sc. The antianoxic effects of Ber was shown to be decreasing O2 consumption of body and raising the ability of body to utilize O2 under the condition of hypoxia.