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zpl, a new gene in drosophila required for neurogenesis

zpl, a new gene in drosophila required for neurogenesis
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摘要 zpl (zip-like) gene mutant embryos showed the cuticular defect with alternative denticle rows and a hole from head to abdomen. zpl mutants also caused the overgrowth of neural cells and axons both in CNS and PNS as well as the wrong pathway of neural fasciculation and the disappearance of hypophysis, as shown by whole mount embryos stained withantibody against HRP and MAb-22C10. Genetic analysis has protided evidence that zpl, located in the right arm ofthe second cliromosome (between 75 and 102 genetic map units), is a new gene closely related to the zip gene. zpl (zip-like) gene mutant embryos showed the cuticular defect with alternative denticle rows and a hole from head to abdomen. zpl mutants also caused the overgrowth of neural cells and axons both in CNS and PNS as well as the wrong pathway of neural fasciculation and the disappearance of hypophysis, as shown by whole mount embryos stained withantibody against HRP and MAb-22C10. Genetic analysis has protided evidence that zpl, located in the right arm ofthe second cliromosome (between 75 and 102 genetic map units), is a new gene closely related to the zip gene.
出处 《Cell Research》 SCIE CAS CSCD 1994年第2期117-125,共9页 细胞研究(英文版)
关键词 果蝇 神经发生 基因表达 zpl ZIP zpl, zip, neurogenesis, fasciculation,drosophila
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