双金连合剂不同给药途径治疗小儿外感发热临床疗效观察

Curative Effect of Different Administration Routes with Shuangjinlian Mixture on Exopathic Fever of Children

目的:观察并对比双金连合剂不同给药途径治疗小儿外感发热的临床疗效及不良反应,以选择最佳给药途径。方法:将122例外感发热患儿随机分成灌肠组和口服组。在常规对症治疗的基础上,灌肠组62例采用双金连合剂灌肠治疗,口服组60例采用双金连合剂口服治疗。观察2组患儿退热起效时间、解热时间及完全退热时间,检测治疗前后血清炎性应激因子白细胞介素(IL)-1β,干扰素(IFN)-γ及肿瘤坏死因子(TNF)-α水平,患儿中医证候积分变化、临床疗效及不良反应情况。结果:灌肠组患儿退热起效时间、解热时间、完全退热时间均短于口服组(P<0.05);与治疗前比较,治疗后2组患儿IL-1β,IFN-γ及TNF-α水平均明显下降(P<0.05),与口服组比较,治疗后灌肠组IL-1β,IFN-γ及TNF-α水平下降更快(P<0.05);治疗后2组患儿中医证候积分均较治疗前下降(P<0.05),且灌肠组下降程度较口服组更明显(P<0.05);总有效率灌肠组为96.78%,口服组为86.66%,灌肠组优于口服组(P<0.05);口服组有3例发生不良反应,灌肠组无不良反应事件发生。结论:应用双金连合剂治疗小儿外感发热,口服和灌肠两种给药途径均取得满意疗效,灌肠给药方法疗效明显优于口服治疗,而且不良反应更少,更易被患儿和家属接受,可作为首选给药途径。

Objective： To compare the effect of different administration routes with Shuangjinlian mixture on exopathic fever of children. Method： A total of 122 children with exopathic fever were randomly divided into clysis group （62 cases） and oral group （60 cases）. Clysis group was given Shuangjinlian mixture by clysis administration, while the oral group was treated with Shuangjinlian mixture by oral administration. Clinical curative effect, scores of traditional Chinese medicine （TCM） symptoms, interleukin （IL）-1β, interferon （IFN）-T and tumor necrosis factor （TNF）-α levels in two groups, and average onset time of fever receding, average antipyretic time and average time of complete fever receding of two groups were observed. Result： The average onset time of fever receding, the average fever antipyretic time and the average time of complete fever receding of the clysis group were significantly shorter than those of oral group （P 〈 0.05）. After treatment, IL-1β, IFN-γ, TNF-α levels in two groups were significantly decreased, with statistically significant differences （P 〈 0.05）. And the two indicators in treatment group were significantly better than those in control group, with significant differences between two groups （P 〈 0.05 ）. The curative effect of the clysis group was obviously superior to that of oral group （P 〈 0.05 ）. Conclusion： Shuangjinlian mixture has a satisfactory clinical efficacy in treating pediatric exogenous fever. Clysisis an effective route of administration and good compliance among children patients, which were better administration, and thus worth of clinical application. Therefore, clysis can be used as the first choice in of children patients with exopathic fever. than oral treatment