居留NK细胞研究新进展及其在肿瘤细胞治疗中的意义

Research progress on tissue resident NK cells and NK cell-based tumor immunology

NK细胞亚群不同表型间存在效应功能的差异,在组织器官的分布也有显著差别。研究证明,肝脏、胸腺、肺脏、子宫、皮肤等组织内存在居留NK细胞,其发育、表型及功能与骨髓中发育、成熟后迁入外周器官的传统NK细胞不同,在维持组织稳态、调控多种重要病理生理过程中发挥作用,与Ⅰ类固有样淋巴细胞具有部分重叠又不完全相同的表型及功能,并且与诱导NK细胞记忆性相关。针对NK细胞尤其是居留NK细胞的研究将为肿瘤免疫治疗提供新的机遇。

NK cells are the first line of defense of the body.Accumulated data has been demonstrated that besides conventional NK cells in the peripheral,there are tissue resident NK cells in liver,thymus,lungs,skin and other tissues.The development,phenotypes and functions of the tissue resident NK cells are different from conventional NK cells,which matured in the bone marrow before moving to peripheral organs.Tissue resident NK cells shares overlapping but different phenotypes and functions with type 1 innate lymphoid cells and play roles in maintenance of tissue homeostasis and induction of NK cells memory.The research on tissue resident NK cells will provide new ideas for NK cells related tumor immunology.