高脂血症与脑损伤、脑神经递质的研究进展

The research progress of hyperlipidemia,brain damage and neurotransmitters

高脂血症引发的炎性反应、氧化应激、脑β淀粉样蛋白沉积等对脑组织造成损伤,通过神经递质产生(抑制)兴奋、影响Ca^(2+)平衡等多种方式介导损伤(抗损伤)效应。本文就近年的相关报道对高脂血症与脑损伤、脑神经递质进行综述。

Hyperlipidemia can damage the brain tissue, by stimulating inflammatory response, enhancing oxidative stress damage and inducting the deposition of amyloid in the brain. It can also interfere with the effect of injury （ anti-inju- ry） by generating （inhibiting） excitability of neurotransmitter and interfering with the balance of the Ca^2＋. This review dis- cusses the relationship between hyperlipidemia, brain damage and neurotransmitters according to the recent reports.