摘要
基于电化学检测法具有无需衍生、高灵敏度、高选择性以及成本低的特点,高效液相色谱-电化学检测法(HPLC-ED)已经成为药物分析的重要工具。从HPLC-ED技术开始使用40年以来,已有大量相关文章和综述发表。本文将对应用在HPLC中的电化学检测器和检测方法进行回顾,重点介绍HPLC-ED技术在药物分析中的最新研究进展,并讨论这种技术的未来发展趋势。
High performance liquid chromatography-electrochemical detection(HPLC-ED) is an important analytical tool for the determination of pharmaceutical drugs since electrochemical detectors provides derivertization-free,sensitive,selective,and low cost detection methods.Numerous papers and reviews have been published since the HPLC-ED techniques were introduced forty years ago.This article will review the electrochemical instruments and detection methods used in HPLC,and focus on recent advances in the analysis of pharmaceutical drugs using HPLC-ED techniques,and discuss the future development trend of the techniques.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2017年第20期1753-1771,共19页
Chinese Pharmaceutical Journal
关键词
高效液相色谱
电化学检测法
药物分析
流通池
脉冲安培检测
high performance liquid chromatography (HPLC)
electrochemical detection (ED)
drug analysis
flow cell
pulsed amperometric detection(PAD)