nCD64与CD14指数对血液肿瘤合并细菌感染的诊断价值

Evaluation of nCD64 and CD14 Index as Diagnostic Markers for Hematologic Tumors Combined with Bacterial Infection

目的:探讨外周血nCD64和CD14指数在血液肿瘤合并细菌感染中的诊断价值。方法:选取血液肿瘤患者64例,其中细菌感染组33例,非感染组31例。用流式细胞仪检测外周血nCD64和CD14相关指标,并计算nCD64 IND及CD14 IND,同时测定WBC、ESR、CRP。结果:两组指标相比,nCD64 IND、CRP差异有统计学意义(P<0.05),CD14 IND、ESR、WBC差异无统计学意义(P>0.05)。绘制ROC曲线,可见曲线下面积CD64 IND(0.974)>CRP(0.786)>ESR(0.675)>WBC(0.598)>CD14 IND(0.556),与标准面积0.5相比CD64 IND、CRP、ESR统计学差异显著(P<0.05),CD14 IND、WBC统计学差异不显著(P>0.05)。结论:nCD64对合并细菌感染的血液肿瘤的诊断具有较高价值,其灵敏度及特异性均高于CRP及ESR。

Objective： To explore the value of both CD64（nCD64 IND） and CD14（CD14 IND） Index of peripheral blood neutrophils as the diagnostic markers of hematologic tumors combined with bacterial infection. Methods： Sixty-four patients with hematological tumors were selected and divided into the group complicated with bacterial infection（infection group,33 cases） and the non-infection group（31 cases）,the flow cytometry was be used to detect the related peripheral blood markers CD64 and CD14,the nCD64 IND and CD14 IND were calculated,and the peripheral blood WBC count,erythrocyte sedimentation rate（ESR） and C-reactive protein（CRP） were determined at the same time. Results：The differences of nCD64 IND and CRP between these 2 groups were statistically significant（P〈 0. 05）,however,the differences of CD14 IND,ESR and WBC between these 2 groups were not statistically significant（ P〈 0. 05）. The receiver operating curves（ROC） were drawn by using the data of all indictors in the 2 groups,and the order of the area under the curve（AUC） from big to small size was as follows： nCD64 IND（0. 974） CRP（0. 786） ESR（ 0. 675） WBC（ 0. 598） CD14 IND（ 0. 556）. The AUC of nCD64 IND,CRP and ESR were statistically significantly different from the standard area of 0. 5（ P〈 0. 05）,while the AUC of CD14 IND,WBC were not statistically significantly different from the standard area of 0. 5（ P〉 0. 05）. Conclusion： nCD64 possesses a high diagnostic value for hematologic tumors with bacterial infection,it＇s sensitivity and specificity both are higher than that of CRP and ESR.