烟曲霉β-1,3-葡聚糖合成酶在分子调控及真菌感染中的作用

Molecular regulation on biosynthesis of β-1,3-glucan on cell wall of Aspergillus fumigatus

烟曲霉是最为常见的重要病原真菌之一,可引起侵袭性曲霉病、变应性支气管肺曲霉病、曲霉肿以及严重过敏性哮喘等多种疾病,病死率高。β-1,3-葡聚糖是烟曲霉细胞壁的主要骨架成份,也是重要免疫原性因子,由β-1,3-葡聚糖合成酶催化生成,该酶主要由催化亚基Fks蛋白和调节亚基Rho1蛋白组成,Rho1可利用自身活性状态转化和修饰调控β-1,3-葡聚糖的合成,也可能通过控制肌动蛋白骨架重排影响Fks胞内转位和功能。该文对β-1,3-葡聚糖的合成的分子调控机制与烟曲霉及其他病原真菌感染进行综述。

As a major pathogenic fungus,Aspergillus fumigatus is able to cause the invasive pulmonary aspergilosis with high mortality,or chronic infection and allergic disease.β-1,3-glucan is not only the back-bone of cell wall of A.furnigatus, but also an essential immunogenic factor.β-1,3-glucan synthase is composed of a catalytic subunit, Fks and regulatory sub- unit, Rhol.Rhol can bind to Fks and regulate the synthesis of β-1,3-gluean through the transformation and modification of its active state.It also may affect cellular translocation and function of Fks by controlling the actin cytoskeleton rearrangement.