JAM-A基因的研究进展

Research Progress of JAM-A

连接黏附分子A(JAM-A)的功能,特别是在肿瘤形成、肿瘤转移以及胚胎发生中的作用是大家关注的热点。JAM-A在肾癌等癌症中的表达与其恶性程度及预后呈负相关,而在乳腺癌中则呈正相关。JAM-A通过整合素α_Vβ_3调控内皮细胞迁移和重排,影响血管新生。JAM-A可通过调节细胞周期使细胞停留在不同时期。JAM-A调控细胞周期的特性在胚胎发育以及肿瘤发生中具有影响细胞增殖的重要作用。JAM-A与细胞紧密连接处的蛋白(ZO-2等)联合激活下游的Rap蛋白,进而调控上皮细胞细胞的屏障功能。由此推测,JAM-A的研究将在肿瘤精准治疗以及胚胎发育调控中发挥作用。

The function of junctional adhesion molecule A（JAM-A）,especially its role in tumor formation,tumor invasion and embryo development is the focus of current research.In renal carcinoma,JAM-A expression is inversely proportional correlated to tumor grade; in mammary cancer,JAM-A is proportional correlated to tumor grade.JAM-A is involved in integrin αvβ3-induced angiogenesis through the regulation on epithelial cell migration.JAM-A can regulate cell cycle and induce cell cycle arrest in different phase,which may have an effect on cell proliferation in embryo development and tumor formation.JAM-A associates with ZO-2 to activate Rap protein and regulate epithelial barrier function.Thus,researches of JAM-A may contribute to cancer precision therapy and embryo development regulation.