肠道菌群与肝硬化关系的研究进展

Research Progress of the Relationship between Intestinal Flora and Cirrhosis

正常肠道菌群具有生物屏障、刺激胃肠道运动、营养消化吸收、免疫调节、促进生长发育等作用,与机体维持动态平衡。一旦平衡打破,可导致肠道菌群失衡,引发和加重各类疾病。肝硬化是各种慢性肝病发展的终末阶段,而肠道菌群失衡在肝硬化演变过程中发挥重要作用。因肝硬化患者存在不同程度的肠道菌群组成改变、细菌代谢活性变化或菌群在局部分布变化,表现为肠道菌群在种类、数量、比例、移位和生物学特性上的变化,故改善肠道菌群失衡有助于肝功能的恢复。未来,纠正肠道菌群失衡将成为肝硬化治疗的主要方向之一。

The normal intestinal flora has the biological barrier,which stimulates gastrointestinal motility,nutrition digestion and absorption,immune regulation,and promotes growth and development,maintaining dynamic balance with the body.Once the balance is broken,it can lead to an imbalance of intestinal flora,causing and aggravating all kinds of diseases.Cirrhosis is the terminal stage of a variety of chronic liver diseases,while intestinal dysbacteriosis plays an important role in the occurrence and process of cirrhosis.Because of existence of different degrees of composition change,bacterial metabolic activity or local distribution of intestinal flora in patients with cirrhosis,with the manifestations of changes of intestinal flora in type,quantity,proportion,shift and biological characteristics,improving the recovery of intestinal flora balance is helpful to the liver function recovery.In the future,correcting the imbalance of intestinal flora will be one of the major directions for the treatment of cirrhosis.