结肠癌辅助化疗的研究进展

Research Progress of Adjuvant Chemotherapy in Colon Cancer

20世纪的多项临床研究确定了辅助化疗在结肠癌治疗中的作用,结肠癌辅助化疗的一线方案是在5-氟尿嘧啶或卡培他滨上联合奥沙利铂,但这主要是针对Ⅲ期结肠癌的患者。对Ⅱ期患者来说,术后发生肿瘤复发、转移的可能性较小,与化疗的毒性作用相比,辅助化疗的作用尚存在争议。老年患者由于合并症及化疗毒性作用等,接受辅助化疗能否获益尚存在争议。

In the 20th century,the effect of adjuvant chemotherapy in colorectal cancer is recommended by a number of clinical studies.The standard chemotherapeutic scheme is 5-fluorouracil or capecitabine combined oxaliplatin.The major scheme is suitable for patients with stage Ⅲ disease,but not for stage Ⅱ.For patients with stage Ⅱ who have lower rate of tumor recurrence and metastasis,considering the drug toxicity reaction of chemotherapy,the benefit of adjuvant chemotherapy remains controversial.Because of multiple complications and drug toxicity reaction,there is also controversy about the benefit from adjuvant chemotherapy for elder patients.