射血分数保留性心力衰竭的研究进展

Research Progress of Heart Failure with Preserved Ejection Fraction

射血分数保留性心力衰竭(HFpEF)是一种复杂的临床综合征,其发病率随着人口老龄化不断增长。然而,目前HFpEF的病理生理机制、评价指标、治疗方法均尚未明确或统一,且临床医师对HFpEF的认识亦存在一定局限性,故对于其临床治疗仍然是最具挑战的病症之一。此外,由于老龄化、肥胖、超重、心房颤动及糖尿病患者不断增多,HFpEF在心力衰竭中的比例亦逐年增长。因此,针对HFpEF患者的高发病率和病死率需要采取更有效的治疗方法,包括诊断、确定疾病状态、评估个体风险概况以及建立个人的治疗策略。

Heart failure with preserved ejection fraction（HFpEF） is a complex clinical syndrome,the incidence of which is increasing with the aging of the population.However,the current pathophysiology of HFpEF,evaluation indicators,treatment methods are not yet clear or unified,and there are some limitations of clinicians on HFpEF awareness,so its clinical treatment is still one of the great challenges.In addition,due to aging,obesity,overweight,atrial fibrillation and continuously increasing diabetic patients,HFpEF in the proportion of heart failure also increased year by year.Therefore,high incidence and mortality rates for HFpEF patients require more effective treatment,including diagnosis,identification of disease status,assessment of individual risk profiles,and establishment of individual treatment strategies.