全基因组关联研究在糖尿病慢性并发症中的研究进展

Advances in Researches on Genome-Wide Association Studies of Diabetic Chronic Complications

遗传与环境因素是影响糖尿病慢性并发症发生、发展的重要因素,全基因组关联研究(GWAS)为探索糖尿病慢性并发症的遗传因素提供了重要的研究工具。近年来,GWAS在糖尿病肾脏病、糖尿病视网膜病变、糖尿病合并心血管事件、糖尿病神经性疼痛及糖尿病足等糖尿病慢性并发症的研究中取得了不同程度的进展,目前已发现和鉴定出了不同并发症的部分相关基因。但GWAS的部分研究结果仍存在争议,更进一步地探索并将GWAS成果运用于临床是今后研究的重要方向之一。

Heredity and environment play significant roles in the development of diabetic chronic complications.Genome-wide association research（GWAS） provides an important research tool for exploring the genetic factors of chronic complications of diabetes mellitus.In recent years,GWAS has made great progress in diabetic nephropathy,diabetic retinopathy,diabetes mellitus with cardiovascular events,diabetic neuropathic pain,diabetic foot and so on.It has been found and identified that there are different related genes of different complications.However,some of the results of GWAS are still controversial,and further exploration and application of GWAS results in clinical research are important research directions in the future.