阴道微生态与生殖道疾病的相关性研究

Correlation between Vaginal Microecology and Reproductive Tract Diseases

女性阴道与外界环境自然相通,使局部阴道微生态系统受宿主与环境的双重制约,多种因素,如外界环境因素的变化、阴道局部解剖结构及机体免疫反应性的变化等均可影响甚至改变阴道局部菌群,造成微生态体系失衡,继而导致生殖道疾病的发生。许多临床上常见的生殖道疾病,如阴道炎、宫颈炎、子宫颈上皮细胞内瘤变、宫颈癌等均存在明显的阴道微生态体系失衡。理解、研究并恢复阴道局部微生态环境的平衡,对生殖道疾病的预防、治疗有重要的临床意义。

The female vagina and the external environment are interlinked naturally, which makes the local vaginal microecologic system be restricted by both the host and the environment, and the changes of various factors such as environ- mental factors,the vagina/local anatomical changes and immune response, can all influence and even change the vaginal flora, causing microecologic system imbalance, and then leading to the occurrence of reproductive tract diseases. Many repro- ductive tract diseases, such as vaginitis, cervicitis, cervical intraepithelial neoplasia, cervical cancer, are all generally found to have micro-ecological imbalance in vagina. To understand, study and pay attention to the balance of microecologic envi- ronment of the vagina is of great clinical significance for the prevention and treatment of reproductive tract diseases.