乳腺癌MRI特征与分子生物学行为的相关性研究

Correlations between the MRI Features of Breast Cancer and Molecular Biological Behavior

乳腺磁共振成像(MRI)具有很好的软组织分辨率和无射线辐射等优点,对乳腺癌的早期诊断和局部分期明显优于乳腺X线摄影和超声检查。随着乳腺癌个体化、规范化综合治疗理念的推广,乳腺MRI在综合治疗中的作用日益受到重视。乳腺癌术前及术后雌激素受体、孕激素受体以及人类表皮生长因子受体2的测定已广泛用于临床。这些因子和基因的表达引起组织学上的改变,可以在影像学上间接或直接地反映出来。目前,乳腺癌的影像学评估方法以MRI最为常用。该文主要探讨MRI影像学特征与生物学预后因子的相关性,在治疗前根据MRI预测乳腺癌的临床特点和预后,为临床治疗方案提供术前指导。

The magnetic resonance imaging （MRI） of breast cancer has the advantages of good soft tissue resolution and no radiation, and it is superior to mammography and uhrasonography in early diagnosis and local staging of breast cancer. With the popularization of individualized, standardized and comprehensive treatment of breast cancer, the role of breast MRI in integrated therapy has been paid more and more attention. Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 have been widely used in the diagnosis of breast cancer before and after operation. The expression of these factors and genes can cause histological changes and can be indirectly or directly detected by imaging. At present, MRI is the most common method of imaging evaluation for breast cancer. Here is mainly to discuss the correlation between MRI imaging features and biological prognostic factors, to provide preoperative guidance for clinical treatment according to the predicted clinical features and prognosis by MRI.