温州地区青少年甲状腺乳头状癌的临床与病理特点

Clinical and pathological characteristics of thyroid papillary carcinoma in adolescents in Wenzhou area

目的探讨温州地区青少年甲状腺乳头状癌(Papillary Thyroid Carcinoma,PTC)的临床及病理特点,提高对青少年PTC的认识。方法总结收集的15年间31例青少年(年龄≤18岁)PTC临床表现、病理类型、ki-67蛋白表达情况,与同期1037例成年人(年龄>18岁)PTC患者作对比。结果青少年组在临床表现(甲状腺孤立性结节、甲状腺结节伴颈部淋巴结肿大)、病理类型(经典型、弥漫硬化型)及预后等方面与成年人组不同(P<0.05);ki-67检测方面与成年组患者并无差异,但两组患者病理分期Ⅲ、Ⅳ期的表达均高于病理分期Ⅰ、Ⅱ期,差异有统计学意义(P<0.05)。结论青少年组PTC的临床表现、病理类型不同于成年组,其预后好,检测ki-67蛋白表达可提示预后并有助于临床分期。

Objective To analyze the clinical and pathological characteristics of thyroid papillary carcinoma（ TPC） in adolescents in Wenzhou area for improving the adolescents＇ s understanding of TPC. Method The clinical manifestations,pathological types and Ki-67 protein expression of 31 adolescent patients（ age ≤18 years old） with PTC over the past fifteen years were firstly collected and compared with those of 1037 adults（ age 18 years old）. Findings The adolescents differed in clinical manifestations（ thyroid solitary nodules, thyroid nodules with neck lymph node enlargement）,pathological types（ classic type,diffuse type hardening） and prognosis with adults group（ P〈0. 05）. No difference was found between the two groups in the detection of Ki-67. However,the pathological staging（ III/IV） expression of both groups was higher than that of the pathological stage（ phase I/II）（ P0. 01）. Conclusion The clinical manifestations and pathological types of PTC in the adolescent group were different from those in the adult group. They have better prognosis.The detection of Ki-67 protein expression can indicate the prognosis and guide clinical treatment.