909例新疆维吾尔族结直肠腺瘤及结直肠早癌相关危险因素分析

The analysis of the risk factors in Uygur in Xinjiang area of the colorectal adenomatous polyosis progressing into the early colorectal cancer

目的探讨新疆维吾尔族结直肠腺瘤患者发生早期结直肠癌的危险因素。方法对新疆维吾尔自治区人民医院消化内镜中心2015年1月至2016年12月经结肠镜检查发现并经病理证实的909例早期结直肠癌及结直肠腺瘤病患者进行回顾性研究及现况调查,分析其临床特征,探讨新疆维吾尔族结直肠腺瘤患者进展为早期结肠癌的危险因素。结果早癌组中年龄、二级及三级亲属以内患结肠癌者、既往胆囊切除史、吸烟史均高于腺瘤组,差异有统计学意义(t=3.139,Χ~2=4.439、10.497、4.479、7.842,P均<0.05)。在饮食习惯的调查中,两组谷物摄入量差异有统计学意义(Χ~2=13.639,P<0.05),早癌组患者进食腌制食物每2~3天1次者多于腺瘤组。蔬菜摄入频率、水果摄入频率、腌制食物进食频率差异没有统计学意义(Χ~2=1.711、6.579、10.461,P均>0.05)。Logistic回归分析发现,年龄≥60岁、三级以内家属恶性肿瘤史、胆囊切除术、吸烟史是结直肠腺瘤癌变为早期结直肠癌的危险因素(OR=2.420,5.632,7.623,5.234,P<0.05)。结论维吾尔族人群中年龄、三级以内亲属、胆囊切除术、吸烟史、是结直肠腺瘤进展为早期结直肠癌的危险因素。

Objective To investigate the risk of the colorectal adenomatous polyosis progressing into the early colorectal cancer. Methods 909 cases of colorectal adenomatous polyosis and early colorectal cancer confirmed by pathology were selected form January 2015 to December 2016, to explore the risk of the colorectal adenomatous polyosis progressing into the early colorectal cancer. Results There was marked diefference in age, secondary and tertiary relatives within the family history of colon cancer, smoking history, gallbladder excision history between the colorectal adenomatous polyosis and the early colorectal cancer（t=3.139, Χ~2=4.439, 10.497, 4.479, 7.842, P 0.05）. In the survey of dietary habits, there wasno marked diefference in the frequency of vegetable intake, the frequency of fruit intake, and the frequency of the pickled food between two groups（Χ~2=1.711、6.579、10.461, P 0.05）, but there was statistically differences in the frequency of grains intake and the patients of the early colorectal cancer eatting the pickled food（2~3 times Per day） were more than the patients of colorectal adenomatous polyosis（Χ~2=13.639, P 0.05）. In the Logistic regression analysis, the age, tertiary relatives within the family history of colon cancer, smoking history, gallbladder excision history maight be the risk of the colorectal adenomatous polyosis becoming into the early colorectal cancer（OR=2.420, 5.632, 7.623, 5.234, P 0.05）. Conclusion The age, tertiary relatives within the family history of colon cancer, smoking history, gallbladder excision history maight be the risk of the colorectal adenomatous polyosis becoming into the early colorectal cancer.