利培酮对首发精神分裂症患者脑电图的影响

The impact on EEG of risperidone in the first episode-inpatients with schizophrenia

目的观察利培酮对首发精神分裂症患者脑电图及脑电功率值的影响。方法应用回顾性分析方法,收集用利培酮单一治疗的首发精神分裂症患者共51例,获取服药前及服药28d后脑电图的结果,然后分析利培酮对首发精神分裂症患者用药前后脑电图有何影响。结果服药前,51例脑电图中有11例异常脑电图;服药28d后,则有19例异常脑电图,多数为轻度异常,少数为中度异常,未见有重度异常。异常表现多为α波慢化,α波波幅降低,散在性的θ波增多,无明显的局灶性改变,也未见异常波形及痫样活动。在脑电功率值方面,利培酮治疗28d后只有θ频带功率值在部分导联上高于服药前(P<0.05)。结论利培酮对精神分裂症患者脑电图有一定影响,但影响不显著。

Objective To observe the effect of risperidone on EEG and electroencephalogram electric power in inpatients with first-episode schizophrenia. Methods We collected EEG results of 51 cases with the method of retrospective analysis of medical records. These patients were treated with risperidone alone and these patients were the first episode of schizophrenia. Then we analyzed the effect of risperidone on patients with schizophrenia. Results There were 11 abnormal electroencephalogram in 51 cases before treatment. However,the number of abnormal electroencephalogram increased to 19 cases after 28 days of treatment. Most of the abnormal EEG were mild abnormal EEG,and only a few were moderately abnormal EEG. There was no severe abnormal EEG. Abnormal expression of α wave slowed down. α wave amplitude was decreased. The scattered θ wave was increased,but there was not significant focal changes,abnormal waveform and epileptiform activity. In the electroencephalogram power value,only the θ band power value after threatment of risperidone for 4 weeks was significant higher statistically than those before the treatment. Conclusion Risperidone impacts the EEG of schizophrenia,however,the impact is not significant.