血清锌α2糖蛋白表达水平与2型糖尿病并发高尿酸血症的关系

Study on the relationship between the expression level of serum zinc a2 glycoprotein and type 2 diabetes mellitus complicated with hyperuricemia

目的研究血清锌d2糖蛋白（ZAG）表达水平与2型糖尿病并发高尿酸血症（HUA）的关系。方法随机抽取2型糖尿病且正常尿酸患者220例（A组）、2型糖尿病并发高尿酸血症患者100例（B组）及健康正常人群80例（c组），对三组临床及生化相关指标、血清ZAG表达水平测定比较，Pearson相关性及多元线性逐步回归分析血清ZAG表达水平与相关指标的关系。结果A、B、C三组血清ZAG水平[（58．89±23．17）mg／LVS（86．42±25．36）mg／LVS（40．65±16．48）mg／L]比较差异有统计学意义（P〈0．05）；Pearson相关性分析显示血清ZAG水平与BMI、TG、HbAlc、Cr、BUN、尿酸（SUA）呈正相关（P〈0．05），与HDL—C呈负相关（P〈0．05）；多元线性逐步回归分析表明BMI、TG、HDL—C是影响血清ZAG水平的独立因素。结论血清ZAG水平在2型糖尿病患者中明显上升，特别是并发HUA患者，其水平上升可能与肥胖、脂代谢紊乱有关，血清ZAG可能参与2型糖尿病并发HUA发病过程。

Objective To investigate the relationship between the expression level of serum zinc α2 glycoprotein （ZAG） and type 2 diabetes mellitus （T2DM） complicated with hyperuricemia （HUA）. Methods A total of 220 patients with T2DM and normal uric acid （group A） , 100 patients with T2DM compli- cated with hyperurieemia （group B） , and 80 cases of normal healthy people （group C） were randomly selected. The clinical and biochemical indexes and expression levels of serum ZAG among three groups were determined and compared. The relationship between expression level of serum ZAG and related indexes was analyzed with Pearson correlation and multiple linear stepwise regression analysis. Results The serum ZAG levels showed significant differences among groups A, B and C [ （ 58.89 ±23.17 ） mg/L vs （ 86. 42 ± 25.36） mg/L vs （40. 65 ± 16. 48）mg/L] （P 〈 0. 05 ）. Pearson correlation analysis showed that serum ZAG level was positively correlated with body mass index （ BMI ）, triglyceride （ TG）, glycosylated hemoglobin （HbAlc）, creatinine （Cr）, urea nitrogen （BUN）, and serum uric acid （SUA） （P 〈0. 05）, and nega- tively correlated with high density lipoprotein cholesterol （ HDL-C ） （ P 〈 0. 05 ）. Multiple linear stepwise regression analysis showed that BMI, TG and HDL-C were independent factors influencing serum ZAG level. Conclusions Serum ZAG level is significantly higher in patients with T2FM, especially in patients complicated with HUA. The increased level may be related to obesity and dyslipidemia, showing that serum ZAG may be involved in the pathogenesis of T2DM complicated with HUA.