炎症相关疾病——糖尿病视网膜病变

Inflammation-linked diseases： diabetic retinopathy

糖尿病性视网膜病变（DR）已成为全球致盲的主要因素之一。目前，在世界范围内大约有2．82亿的糖尿病患者。然而，糖尿病视网膜病变的发病机制是复杂的，有血管、炎症和神经机制参与。近年来研究发现，许多炎症因素如白细胞浸润、黏附分子及许多炎症因子的表达与DR的发生、发展密切相关；许多抗炎药物可通过抑制白细胞积聚、降低炎症因子表达等过程，阻止或减缓DR的发生与发展。因此，对DR炎症发病机制的深入理解有助于探索新的治疗途径，延缓DR的发生发展。

Diabetic retinopathy （DR） has become one of the main factors of global blindness. Worldwide, there are about 282 million patients with diabetes. The pathogenesis of DR is complex and sev- eral vascular, inflammatory, and neuronal mechanisms are involved. In recent years, the study has found that inflammatory factors such as leukocyte infiltration, the expression of adhesion molecules and many in- flammatory factors are closely related with the occurrence and development of DR; many anti-inflammatory drugs can inhibit leukocyte accumulation, reduce the inflammation factor expression, and prevent or slow the occurrence and development of DR. Therefore, in order to explore new treatment to delay the occurrence of DR, we should better understand the DR pathogenesis.