4890对孕前优生检查夫妇乙肝病毒感染现状调查

Investigation of HBV infection status of prenatal eugenics examination by 4890 pairs

目的分析和总结山东省济宁市某区4 890对计划怀孕夫妇乙肝病毒的感染状况,为本地区孕前优生健康指导、控制乙肝病毒传播和实施母婴传播阻断提供参考依据。方法对2015-2016年在济宁市妇幼保健计划生育服务中心进行免费孕前优生健康检查的4 890对夫妇用酶联免疫吸附试验(EILSA法)检测乙肝五项:乙肝表面抗原(HBs Ag)、表面抗体(HBs Ab)、e抗原(HBe Ag)、e抗体(HBe Ab)、核心抗体(HBc Ab),并对于检测结果进行回顾性统计学分析。结果受检人群乙肝病毒感染率5.7%,并经临床进一步确诊,男性高于女性。乙肝表面抗体阳性(包括单纯打过疫苗的阳性和感染乙肝并产生抗体)者占51.9%。未感染乙肝病毒同时抗体阴性者占42.4%。结论本研究发现本地区近两年来孕前夫妇乙肝病毒感染率暂低于全国平均水平,但未感染者中抗体阴性者比例较高。

Objective To analyze and summarize the HBV infection status among 4 890 pairs of planned pregnancy couples in one district of Jining City, Shandong Province, and provide reference for prenatal health guidance, control of HBV transmission and mother-to-child transmission blocking. Methods A total of 4 890 coupleswith free prenatal eugenics examination from 2015 to 2016 in Jining Maternal and Child Health Care Family Planning Service Center were enrolled in this study. HBsAg, HBsAb, HBeAg, HBeAb,HBcAb were detected by enzyme-linked immunosorbent assay（EILSA） and the results were analyzed retrospectively. Results The infection rate of HBV was 5.7% which were also confirmed by the orther clinical examnation, the rate in male was higer than female. HBs Ab positive（including the vaccinees and infections） was accounted for 51.9%. HBV infection negative with HBs Ab negative meanwhile was accounted for 42.4%. Conclusion This study was revealed that the HBV infection of couples before pregnancy in this region was lower than the national average in the past two years, but the proportion of HBs Ab negative in the non-infected patients was higher.