摘要
目的 :为探讨中药健脾降糖饮防治糖尿病 (DM )慢性并发症的机理。方法 :用舌下静脉注射四氧嘧啶 (Alloxam)的方法制作糖尿病动物模型 ,观察健脾降糖饮对DM大鼠空腹血糖、血液流变、血清肿瘤坏死因子 (TNFα)和血小板膜糖蛋白 (GMP14 0 )的影响。结果显示健脾降糖饮可显著增加体系 ,降低血糖、降低血清肿瘤坏死因子 (TNFα)和血小板膜糖蛋白 (GMP 14 0 ) (P均 <0 0 1)。健脾降糖饮对TNFα和GMP 14 0的干预可能是该方防止DM慢性并发症的机理之一。
To explore the preventive and curative mechanism of Jianpijiangtang Solution(JS) on diabetes mellitus and its chronic complications,we observed the effect of JS on blood sugar、serum TNF α and platelet GMP140 of diabetes mellitus rats induced by alloxan,the results shows that JS can lower blood suggar、lower serum TNF α and platelet GMP140.The effects of JS on TNF α and GMP140 are of great importance in diabetes mellitus and its chronic complications.
出处
《中国中医基础医学杂志》
CAS
CSCD
2002年第8期23-24,38,共3页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
健脾降糖饮
四氧嘧啶
糖尿病
大鼠
TNFΑ
GMP-140
Diabetes
Complication
Tumor Necrosis Factor(TNF) α
Granule Membrane Protein 140(GMP 140),Jianpijiangtang Solution(JS)
