益气活血对红细胞变形性作用的实验研究

Effect of Replenishing Qi and Promoting Blood Circulation and Removing Blood Stasis on Erythrocyte Deformability in Rats

目的 :观察使用益气活血药物对大鼠红细胞变形性的作用。方法 :在不同切应力下 ,对使用益气活血药物 (人参丹参 )、活血化瘀药物 (丹参 )、未用药物的老龄大鼠 (18个月 )及未用药物的年轻 (12个月龄 )大鼠等 4组采用激光衍射法 ,分别观察、测定其集群红细胞的平均变形能力。结果 :老龄组与年轻组、药物组与未用药物组、益气活血药物组与活血化瘀药物组之间的红细胞变形指数存在显著差异 (P <0 0 5～ 0 0 1)。结论 :老龄大鼠红细胞变形能力降低 ,益气活血及活血化瘀法均能改善红细胞变形能力 ,人参丹参合用的益气活血法较单独使用丹参的活血化瘀法有更强的改善红细胞变形能力的作用。

Object:To study the effect of replenishing Qi and promoting blood circulation and removing blood stasis on erythrocyte deformability.Methods:Thirty wistar rats,18 months old,were randomly divided into 3 groups,the Ren Shen and Dan Shen treated group,the Dan Shen treated group,the model group,10 in each group.Another 10 wistar rats,12 months old,were the contral group.Erythrocyte deformability was measured by laser diffractometry in these groups.Result:Erythrocyte deformability indix (DI)in the treated groups were higher significantly than the model group( P <0.01).Erythrocyte deformability indix in the Ren Shen and Dan Shen treated groups was higher than the Dan Shen treated group.Conclusion:Administration of replenishing Qi and promoting blood circulation and removing blood stasis increase erythrocyte deformability indix and could improve erythrocyte deformability in rats.