卡马西平与托吡酯单药治疗初诊儿童癫痫的效果分析

Analysis on the effect of carbamazepine and topiramate monotherapy on children with epilepsy

目的分析卡马西平与托吡酯单药治疗初诊儿童癫痫的效果。方法选择100例初诊儿童癫痫患者为研究对象，采用随机数字法将其分为对照组和观察组。对照组给予卡马西平治疗，观察组给予托吡酯单药治疗，观察记录两组患儿的临床疗效和不良反应。结果观察组有效率为96.00%，明显高于对照组的82.00%，差异有统计学意义（χ^2＝5.005，P＝0.025）；对照组出现轻度不良反应40例，中度不良反应8例，重度不良反应2例；观察组出现轻度反应44例，中度不良反应6例，重度不良反应0例。对照组不良反应发生情况明显多于观察组，差异有统计学意义（P〈0.05）。结论卡马西平与托吡酯单药治疗初诊儿童癫痫患儿都有很好的效果，但托吡酯单药效果优于卡马西平，且托吡酯单药的安全性高于卡马西平，但都需适量使用。

Objective To analyze the effect of carbamazepine and topiramate monotherapy on children with newly diagnosed epilepsy. Methods One hundred cases of newly diagnosed children with epilepsy were selected as the research objects, and were divided into the control group and the observation group by random number method. The control group was given the carbamazepine treatment, observation group received topiramate monotherapy, the clinical efficacy was recorded and the adverse reaction of the two groups were obsereved. Results The effective rate of observation group was 96.00%, which was significantly higher than that of the control group （ 82.00% ）, the difference between the two groups was significant （ χ^2 = 5. 005, P = 0. 025 ）. The control group had 40 cases of mild adverse reactiens, 8 cases of moderate adverse reactions, 2 cases of severe; and thoses in the observation group were 44 cases, 6 cases and 0 case, respectively. The adverse reaction in the control group was significantly more than that in the observation group, the difference was significant （P 〈 0. 05）. Conclusions Carbamazepine and topiramate monotherapy has good effect on children with newly diagnosed epilepsy, but compared with carbamazepine, the effect of topiramate alone is better, which is safer, but they should be used in moderation.