摘要
背景 心肌缺血/再灌注损伤（ischemia/reperfusion injury， I/RI）是临床最常见的损伤之一，微小RNA（microRNA， miRNA）参与了其进程。 目的 对心肌I/RI过程中miRNA作用的最新进展进行综述。 内容 回顾并展望miRNA在心肌缺血/再灌注中的作用。 趋向 miRNA与心肌I/RI密切相关，更多以miRNA为靶点的治疗会被用于心肌保护。
Background Myocardial ischemia/reperfusion injury（I/RI） is one of the most common heart injuries in the clinics. MicroRNA（miRNA） involve in the pathophysiological processes, and might be therapeutic targets for myocardial protection. Objective To review recent progress in discovering important miRNAs that attenuate or exacerbate myocardial I/RI. Content Multiple factors and signaling transduction pathways are implicated in heart damage in myocardial I/RI. This review focuses 16 miRNAs that were demonstrated to regulate particular factors or pathways, and modulate angiogenesis, and myocardial apoptosis and necrosis, resulting in either myocardial protection or exacerbation of myocardial necrosis following myocardial ischemia/reperfusion. Trend Above-mentioned miRNAs might be potential targets for myocardial protection to treat myocardial I/RI, while further investigations are warranted to clarify signaling pathways and physiological or pathophysiological status influencing regulatory patterns of these miRNAs.
作者
聂往
王海英
喻田
Nie Jia Wang Haiying Yu Tian(Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College ,Zunyi 563000, China Department of Anesthesiology, Zunyi Medical College, Zunyi 563000, China)
出处
《国际麻醉学与复苏杂志》
CAS
2017年第10期953-957,共5页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金（81560593）
