头孢哌酮舒巴坦对耐碳青霉烯鲍曼不动杆菌致老年医院获得性肺炎的作用

Effect of cefoperazone sulbactam on hospital-acquired pneumoniat caused by carbapenem-resistant acinetobacter baumannii in elderly patients

目的探索含有头孢哌酮舒巴坦(CFS)的抗感染治疗对感染碳青霉烯耐药鲍曼不动杆菌(CRAB)的老年医院获得性肺炎(HAP)病人的体内外抗菌效果。方法选取63例老年HAP病人感染CRAB的临床病例,根据治疗中是否有CFS分为2组,对比分析2组间的疗效差异。同时选取临床分离的50株CRAB菌株进行包含CFS的联合药敏实验。结果 (1)采用CFS的治疗组30 d生存率是94.4%,未采用CFS的对照组30 d生存率是70.4%,2组比较差异有统计学意义(P<0.05)。(2)CFS与米诺环素、左氧氟沙星或美罗培南联用时,主要表现为协同及相加作用。结论含有CFS的药物组合对感染CRAB的老年HAP病人有很好的治疗效果。

Objective To explore the effect of cefoperazone sulbactam（ CFS） on hospitalacquired pneumonia（ HAP） in elderly patients caused by carbapenem-resistant acinetobacter baumannii（ CRAB）. Methods Sixty-three elderly cases of HAP caused by CRAB were selected,and they were divided into two groups according to whether the treatment contained CFS. 30-day survival rate of the two groups were compared. Meanwhile,50 strains of CRAB isolated from clinical patients were used for combined drug sensitivity test. Results The 30-day survival rate of patients treated with CFS was94. 4%,compared with 70. 4% in non CFS group（ P〈0. 05）. CFS combined with levofloxacin,meropenem or minocycline,mainly showed synergistic and additive inhibitory effect on CRAB strains in vitro. Conclusions The antimicrobial drug combinations containing CFS has a good effect on HAP in elderly patients caused by CRAB.