p53调控肿瘤与衰老平衡的研究进展

The research progress of p53 regulating the balance of tumor and aging

衰老和肿瘤一直是科学研究的两个重要课题,健康长寿的生活已是人们追求的目标,但是各种因素致使肿瘤的死亡率、患病率日益提升。值得注意的是,衰老和肿瘤这两个看似截然相反的生物学后果之间存在着共享的分子机制,从这些共享机制中找到平衡点,有利于人们提高生活质量、延长寿命。p53在这个过程中有着积极的作用,对大象和小鼠的研究证明高表达且受控制的p53会提高机体对于肿瘤的耐受性,同时还不会导致过早衰老、寿命缩短现象的发生。文章总结了p53在衰老和肿瘤中的调节作用。

Aging and tumor have been two important topics in scientific research, while more and more people pursue health and longevity. The morbidity and mortality of tumor are still increasing because of various factors. Although tumor and aging seem contrary, they also have many similar regulatory mechanisms. Looking for the balance points among these sharing mechanisms maybe help to improve life quality and lengthen lifespan. The gene of p53 plays an active role in these processes. It has been reported that high expression of p53 under control in elephant and mice can increase the body tolerance to tumor, and can＇t result in the occurrence of premature aging and lifespan shortening. The regulatory effects of p53 in aging and tumor are summarized in this review.