抗T2DM药治疗阿尔茨海默病研究进展

Research progress of anti-T2DM drug for treatment of Alzheimer's disease

阿尔茨海默病(Alzheimer’s disease,AD)的发病机制还不清楚,目前治疗或预防AD的方法效果有限。糖代谢减弱和胰岛素信号紊乱是AD与2型糖尿病(type 2 diabetes mellitus,T2DM)的共同特征,也是T2DM早发AD的主要机制。T2DM相关治疗药物能有效改善AD神经退行性病变,已引起广泛关注。本文总结抗T2DM药物治疗AD研究进展,为AD发病机制和药物研发提供思路。

Pathogenesis of Alzheimer＇s disease（AD） is not clear, and the effects of the present method to cure or to prevent AD are limited. AD shares some common features with type 2 diabetes mellitus（T2DM）, such as decreased glucose metabolism and insulin signaling pathway disorder, which may be related to the fact that patients with T2DM usually early get AD. Researches which reported that several drug treating T2DM in clinic could improve pathologic change of AD has drawn extensive attention. The review not only summaries research progress of certain drug curing T2DM for AD but also hope to provide new ideas to understand the pathogenesis of AD and to develop new drug.