氧化磷酸化的呼吸链途径模式概论

Summary on respiratory chain pathway models of oxidative phosphorylation

线粒体内氧化供能过程中的重要代谢物主要有丙酮酸、三羧酸循环中间体、氨基酸分解产物、酮体、脂肪酸β-氧化中间体、甘油代谢物、嘧啶碱基分解产物等。线粒体内重要代谢物脱下的电子对或者H原子可以通过复合体Ⅰ、复合体Ⅱ、或者通过辅酶Q等不同方式进入呼吸链进行电子传递并生成不同数量的ATP。因此,依据代谢物成对电子或H原子进入呼吸链的方式可以划分不同的氧化呼吸链途径模式:NADH氧化呼吸链途径、琥珀酸氧化呼吸链途径,以及FADH2氧化呼吸链途径。

There are many important metabolites in the process of biological oxidation in mitochondria, such as pyruvate, intermediates of tricarboxylic acid cycle, products of amino acid decomposition, ketone bodies, intermediates of fatty acid β-oxidation, glycerol metabolites, products of pyrimidines decomposition, etc. The paired electrons or H atoms removed from important metabolites in mitochondria entering into the respiratory chain through Complex Ⅰ, Complex Ⅱ, or Co Q and were transferred along the respiratory chain to generate energy and synthese different quantity ATP. According to the different ways of the paired electrons or H atoms removed from metabolites entering into the respiratory chain, the oxidation respiratory chain model would be divided into： NADH respiratory chain pathway, succinic acid respiratory chain pathway, and FADH2 respiratory chain pathway.