长链非编码RNA在膀胱癌中的研究概况

The present status of lncRNA in bladder caner

随着二代测序技术的广泛应用和基因层面上肿瘤学研究的深入,曾被忽略、被低估的lncRNA被揭示与人类肿瘤的发生发展密切相关,从不同的生物学途径影响肿瘤的发生、发展。研究发现,lncRNA与膀胱癌的增殖、浸润、转移、复发、耐药等密切相关。本文将对lncRNA在膀胱癌中的研究概况进行综述。

Taking advantage of next-generation sequencing technology, transcriptomic changes in tumors have been investigated, Long noncoding RNAs(lnc RNAs) are non-protein coding RNAs regulating gene expression,It have been ignored that long noncoding RNA abnormal expression was closely correlated with tumor for a long time. Now it is fully believed that lnc RNA was closely related to bladder tumor cell proliferation,invasion,metastasis, recurrence and drug resistence. This article reviews the present status of lnc RNA in bladder caner.