人参茎叶皂甙对家兔慢性高脂血症的脂质调节及抗过氧化脂质作用

THE EFFECTS OF GINSENOSIDES OF STEM AND LEAF(GSL)ON THE LIPID REGULATION AND LIPID PEROXIDATION IN THE CHRONIC HYPER-LIPIDEMIC RABBITS

用家兔制作高脂血症模型,将32只家兔平均分为4组;正常饲料对照组,高脂饲料对照组,30mg/kg人参茎叶皂甙(GSL)高脂饲料组,60mg/kgGSL高脂饲料组。在实验第24天去掉高脂饲料给普通正常饲料,第42天实验结束。结果表明:GSL能降低血清脂质含量,降低总胆固醇与低密度脂蛋白胆固醇的比值,高剂量的GSL能升高血清高密度脂蛋白胆固醇的含量。GSL还能降低动脉壁脂质含量及心、肝组织内总胆固醇水平,也能降低血清及以上各组织内丙二醛含量。

Thirty two rabbits were divided into 4 groups: (1) Normal diet control group, ( 2 ) Hyperlipid diet control group, ( 3 ) Hyperlipid diet group injected with 30 mg/kg GSL, ( 4 ) Hyperlipid diet group injected with 60 mg/kg GSL, The whole expeiment took about 42 days. On 24d all hyperlipid diet were removed, and only normal diet given. At the end of this experiment all rabbits were killed by bleeding and the results showed that GSL could decrease the serum lipids GSL could increase the HDL - C in the rabbits injected with 60 mg/kg GSL. GSL could protect the walls of aortas from the damage of hyperlipid serum. The contents of lipid and MDA in the Walls of aortas were decreased. GSL had the effects of protection on the heart and liver by decreasing of Total Cholesterol and MDA. So we conclude that GSL has the effects of lipid regulation and lipid antipeoxidation on the chronic hy-perjipidemic rabits.