持续气道正压呼吸联合珂立苏治疗新生儿呼吸窘迫综合征的疗效观察

Observation of curative effect of continuous positive airway pressure combined with calsurf in treating neonatal respiratory distress syndrome

目的分析研究持续气道正压(CPAP)呼吸和珂立苏防治新生儿呼吸窘迫综合征的临床效果。方法选取新生儿呼吸窘迫综合征患儿92例,随机分成观察组和对照组,各46例,对照组仅采用常规疗法+CPAP,观察组在常规治疗基础上给予CPAP+珂立苏治疗,比较分析两组患者的血氧饱和度(SpO_2)、自主呼吸改善情况、血气变化、临床疗效及并发症发生情况。结果与对照组比较,治疗12h后观察组患儿的SpO_2指标、自主呼吸改善成功率、PaO_2均明显升高,PaCO_2降低显著;各组间治疗前后变化及组内治疗前后的比较差异具有显著性;观察组治疗总有效率(95.66%)明显高于对照组(69.57%)(P=0.0094),且并发症较低。结论采用CPAP联合珂立苏的方法治疗早产新生儿呼吸窘迫疗效显著,未见明显并发症,值得临床推广。

Objective For the prevention and treatment of neonatal respiratory distress syndrome,the analysis and research for the clinical effect of continuous positive airway pressure（ CPAP） breathing and Calsurf were conducted.Methods 92 patients with neonatal respiratory distress syndrome were selected and randomly divided into the observation and the control group（ n = 46）.The control group only received the routine therapy ＋CPAP while the observation group was treated with CPAP and Calsurf on this base. The oxygen saturation（ SpO_2）,spontaneous breathing,blood gas change,clinical efficacy and complications incidence of patients were compared and analyzed. Results Compared with the control group,after treatment for 12 h,SpO_2,independent respiratory improvement success rate and PaO_2 in the observation group were obviously higher（ P = 0. 0246）,and the PaCO_2 was significantly lower. The difference between the two groups before and after treatment was statistically significant（ P = 0. 0108）. The difference between the intergroups and intragroups were statistically significant.In addition,the total efficiency（ 95.66%） of the observation group was significantly higher than that of control group（ 69. 57%）（ P = 0. 0094）,and no complication was observed. Conclusion The combination of CPAP and Calsurf methods in treating neonatal respiratory distress syndrome made a significant clinical effect,which is worthy of being clinically promoted.