微量白蛋白尿及脉压差与冠心病的相关性

Correlation between microalbuminuria and pulse pressure and coronary heart disease

目的:观察微量白蛋白尿及脉压差与冠心病的相关性,探讨上述指标在冠心病的早期诊断、预防以及治疗中的价值。方法:选取接受冠状动脉造影术检查的患者180例为研究对象,根据冠状动脉造影结果分为非冠心病组(60例)和冠心病组(120例),冠心病组中冠状动脉单支血管病变组35例、双支血管病变组39例、三支血管病变组46例,比较各组患者微量白蛋白尿以及脉压差水平。结果:冠心病组患者尿微量白蛋白水平高于非冠心病组(t=937.660,P=0.000);此外,冠心病组脉压差高于非冠心病组(t=2.060,P=0.042);各冠状动脉病变支数组间尿微量白蛋白比较,差异有统计学意义(F>999.990,P=0.000),同时,各组间脉压差比较,差异有统计学意义(F=3.822,P=0.023);Logistic回归分析结果显示,脉压差及微量白蛋白尿与冠心病的发生均有相关性(P<0.05)。结论:微量白蛋白尿以及脉压差与冠心病具有一定的相关性,微量白蛋白尿、脉压差是冠心病的独立危险因素。

Objective： To study the correlation between microalbuminuria and pulse pressure and coronary heart disease and to explore the value of early diagnosis,prevention and treatment of coronary heart disease. Methods： 180 cases of patients examined by coronary angiography were divided non-coronary heart disease group（ 60 cases） and coronary heart disease group（ 120 cases） by the results. In the coronary heart disease group,there were 35 cases in single vessel disease grade,39 cases in double vessel disease grade and 46 cases in three vessel disease grade. The levels of microalbuminuria and pulse pressure in each group were compared. Results： The level of microalbuminuria in coronary heart disease group was significantly higher than that in non-coronary heart disease group（ t = 937. 660,P = 0. 000）. The pulse pressure in coronary heart disease group was significantly higher than that in non-coronary heart disease group（ t = 2. 060,P = 0. 042）. There was statistically significant difference of microalbuminuria in the three coronary heart disease groups（ F 〉 999. 990,P = 0. 000） and there was significant difference of pulse pressure in the three groups（ F = 3. 822,P = 0. 023）. Logistic regression analysis showed that pulse pressure and microalbuminuria were correlated with the occurrence of coronary heart disease（ P 〈 0. 05）. Conclusion： Pulse pressure and microalbuminuria are correlated with coronary heart disease. Pulse pressure and microalbuminuria are independent risk factors for coronary heart disease.