摘要
A glycosylamino acid "cassette"-based synthetic route has been developed for the preparation ofvasopressin analogues with glycosylation. This efficient protocol may be utilized in the synthesis of other novel cyclic glycopeptide structures and derivatives.
本文建立了以糖-氨基酸缀合物作为固相合成模块、快速制备人血管加压素糖基化衍生物的策略,为高效合成其它结构新颖的糖基化环肽及衍生物提供了一个解决方案。
基金
Peking University Health Science Center(BMU20130354),State Key Laboratory of Natural and Biomimetic Drugs,and the National Recruitment Program of Global Youth Experts(1000 Plan)