脉血康联合阿司匹林治疗急性缺血性脑卒中的疗效观察

Observation on efficacy of acute ischemic stroke treated with Maixuekang combined with aspirin

目的探讨脉血康联合阿司匹林治疗急性缺血性脑卒中的疗效。方法 96例急性缺血性脑卒中患者,随机分为脉血康组(31例)、双抗组(33例)和对照组(32例)。脉血康组使用脉血康胶囊联合阿司匹林治疗,双抗组使用氯吡格雷联合阿司匹林治疗,对照组单用阿司匹林治疗,比较三组治疗效果。结果三组患者在入院时及治疗后7 d时的美国国立卫生研究院卒中量表(NIHSS)评分比较差异无统计学意义(P>0.05)。治疗后14、90 d时,脉血康组和双抗组NIHSS评分优于对照组(P<0.05),但脉血康组与双抗组NIHSS评分比较差异无统计学意义(P>0.05)。三组治疗后7 d时的NIHSS评分与入院时比较差异均无统计学意义(P>0.05);而治疗后14、90 d时的NIHSS评分均低于入院时,差异具有统计学意义(P<0.05)。三组7 d内NIHSS评分增加≥2分患者数量均为5例,三组间两两比较差异均无统计学意义(P>0.05)。所有患者中出现2例药物引起的消化道出血,均发生在双抗组,经停药治疗后好转。结论脉血康联合阿司匹林治疗急性缺血性脑卒中的疗效与氯吡格雷联合阿司匹林疗效相似,优于单用阿司匹林患者。

Objective To investigate the efficacy of acute ischemic stroke treated with Maixuekang combined with aspirin. Methods A total of 96 acute ischemic stroke patients were randomly divided into Maixuekang group（31 cases）, double resistance group（33 cases） and control group（32 cases）. Maixuekang group was treated with Maixuekang capsules and aspirin, double resistance group was treated with clopidogrel and aspirin, and the control group was treated with aspirin. Treatment effect in three groups was compared. Results Three groups had no statistically significant difference in National Institutes of Health Stroke Scale（NIHSS） score at admission and 7 d after treatment（P〉0.05）. after 14 and 90 d of treatment, Maixuekang group and double resistance group had better NIHSS score than the control group（P〈0.05）, but there was no statistically significant difference in NIHSS score between Maixuekang group and double resistance group（P〉0.05）. Three groups had no statistically significant difference in NIHSS score after 7 d of treatment than at admission（P〉0.05）, and lower NIHSS score at 14 and 90 d after treatment than at admission. The difference was statistically significant（P〈0.05）. Three groups had 5 cases with NIHSS score increased≥2 points within 7 d, and there was no statistically significant difference in pairwise comparison（P〉0.05）. There were 2 cases of drug-induced gastrointestinal bleeding in double resistance group, and improved after discontinuation of the drug. Conclusion Combination of Maixuekang and aspirin shows similar efficacy in treating acute ischemic stroke with clopidogrel and aspirin, and better efficacy than patients with simple aspirin.