硝苯地平缓释片对高血压治疗的临床疗效观察

Observation on clinical efficacy of nifedipine sustained release tablets in the treatment of hypertension

目的研究硝苯地平缓释片对高血压治疗的临床疗效。方法 60例高血压患者作为研究对象,依据信封式随机分组原则分为A组及B组,各30例。A组给予缬沙坦单一治疗,B组于A组的基础上给予硝苯地平缓释片治疗。比较两组干预后的收缩压(SBP)、舒张压(DBP)、临床效果及不良反应情况。结果治疗后,两组SBP、DBP水平均较本组治疗前降低,且B组降低程度优于A组,差异均具有统计学意义(P<0.05)。B组总好转率为96.67%,高于A组的73.33%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论给予硝苯地平缓释片治疗的效果显著,可明显降低机体内血压水平,且具有一定安全性,值得在临床中推广实施。

Objective To study the clincial efficacy of nifedipine sustained release tablets in the treatment of hypertension. Methods A total of 60 hypertension patients as study subjects were divided by envelope method into group A and group B, with 30 cases in each group. Group A was treated with valsartan, and group B was treated with nifedipine sustained release tablets on the basis of group A. Comparison were made on systolic blood pressure（SBP）, diastolic blood pressure（DBP）, clinical effects and adverse reactions after intervention between two groups. Results After treatment, both groups had lower SBP and DBP level than before treatment, and group B had better decline degree than group A. Their difference was statistically significant（P〈0.05）. Group B had higher total improvement rate as 96.67% than 73.33% in group A, and the difference was statistically significant（P〈0.05）. Both groups had no statistically significant difference in incidence of adverse reactions（P〉0.05）. Conclusion Nifedipine sustained release tablets provides remarkable effect, and it can obviously reduce the blood pressure level in the organism with certain safety. So it is worthy of popularization and implementation in clinic.