百令胶囊对慢性肾脏病患者相关炎性因子的影响

Influence of Bailing capsule on the serum levels of hs - CRP, IL - 18, TNF - α in patients with chronic kidneydisease

目的观察百令胶囊对慢性肾脏病（CKD）患者超敏C反应蛋白（hs-CRP）、白细胞介素18（IL-18）、肿瘤坏死因子α（TNF-α）的影响。方法56例早期CKD患者，采用随机数字表法分为对照组（28例）及治疗组（28例），另选20名健康体检者作为健康对照组，治疗组在常规治疗基础上加用百令胶囊每次4粒口服，每天3次，共12周，治疗前、后分别检测hs-CRP、IL-18、TNF．Ot、BUN及Scr。结果对照组及治疗组CKD患者its—CRP、TNF-α、IL-18、BUN及Scr治疗前明显高于健康对照组[（5．99±2．67）、（6．17±2．23）mg／L比（2．27±2．16）mg／L，（4J4．43±7．54）、（46．54±8．63）μg／[．比（11．42±3．32）μg／L，（95．22±34．65）、（105．48±33．25）mmol／L比（21．34±10．10）ng／L，（6．86±2．97）、（6．89±2．85）．mmol／L比（5．32±2．43）mmol／L，（98．47±28．85）、（95．46±27．83）μmol／L比（75．454-28．20）μmol／L，均P〈0．05]，对照组12周后其hs-CRP、IL-18、TNF-α、Scr及BUN均有所降低，但差异无统计学意义（t=-0．22、-1．30、-1．75、-0．67、-1．16，均P〉0．05），而治疗组治疗后其bs．CRP、IL-18、TNF-α及Scr明显降低（t=-2．77、-3．81、-4．71、-2．06，均P〈0．05）。结论百令胶囊能有效改善CKD患者的微炎症状态，延缓CKD的进展。

Objective To observe the influence of Bailing capsule on the serum levels of hs - CRP, IL - 18, TNF -α in patients with chronic kidney disease （CKD）. Methods According to the digital table,56 CKD patients were randomly divided into the control group （28 cases） and treatment group （treated with Bailing capsules,28 cases）. Meanwhile,20 healthy adults were selected as the normal controls. The blood concentrations of hs - CRP, IL - 18, TNF -α,Scr and BUN were determined. Results The levels of hs - CRP,IL - 18,TNF - α,Scr and BUN in CKD patients were significantly higher than those in the normal control [ （ 5.99± 2.67 ） mg/L, （ 6.17 ± 2.23 ） mg/L vs. （2. 27 ±2. 16） mg/L, （44.43 ± 7.54） p.g/L, （46.54± 8.63） μg/L vs. （ 11.42 ± 3.32） μg/L, （95.22 ± 34.65 ）ng/L, （ 105.48 ± 33.25 ） ng/L vs. （21.34 ± 10.10 ） ng/L, （ 6.86 ±2.97 ） mmol/L, （ 6.89 ± 2.85 ） mmol/L vs. （ 5.32 ± 2.43 ） mmol/L, （98.47 ± 28.85 ）μmol/L, （ 95.46 ± 27.83 ）μmol/L vs. （75.45 ±28.20 ） μmol/L, all P 〈 0.05 ]. The levels of hs - CRP, IL - 18, TNF - α, Scr and BUN decreased after 12 weeks of conventional treatment （ t = - 0.22, - 1.30, - 1.76, - 0.67, - 1. 16, all P 〉 0.05 ） , while those were significantly decreased with Bailing capsule treatment （ t = - 2.77, - 3.81, - 4.71, - 2.06, all P 〈 0.05 ）. Conclusion The renal inflammation can be alleviated by Bailing capsule in CKD patients, which can slow the progression of CKD.