布地奈德混悬液联合抗生素治疗小儿急性中耳炎的疗效观察

Clinical observation of budesonide suspension combined with antibiotics in the treatment of children with acute otitis media

目的观察布地奈德混悬液联合抗生素治疗小儿急性中耳炎的临床疗效。方法选取绍兴市中心医院2016年1-12月256例急性中耳炎患儿，采用随机数字表法分为观察组和对照组，每组128例。两组患儿均给予抗生素治疗（阿洛西林钠），在此基础上观察组患儿给予布地奈德混悬液治疗，对照组患儿给予氯霉素滴耳液治疗。治疗结束后，比较两组治疗效果。结果与对照组比较，观察组听力改善程度明显提高（x2=21．05，P〈0．01），鼓室积液率显著降低（t=15．30，P〈0．01），鼓室压有效降低率高（t=10．61，P〈0．01）。观察组临床症状积分明显减少，改善程度远优于对照组（t=16．99，P〈0．01）。观察组起效时间、住院时间均明显缩短差异均有统计学意义（t=13．37、13．89，均P〈0．01）。观察组临床总有效率为95．3％，对照组为78．9％，两组差异有统计学意义（x2=20．19，P〈0．01）。观察组不良反应发生率明显低于对照组，差异有统计学意义（x2=8．07，P〈0．05）。结论布地奈德混悬液联合抗生素治疗小儿急性中耳炎疗效显著，有利于减少鼓室积液形成，改善患儿的听力，提高治疗效果，值得临床进一步推广应用。

Objective To observe the clinical efficacy of budesonide suspension combined with antibiotics in the treatment of children with acute otitis media. Methods 256 children with acute otitis media in Shaoxing Central Hospital from January 2016 to December 2016 were selected, and they were randomly divided into observation group and control group by using the method of random number table, 128 cases in each group. Both two groups were given antibiotic therapy （azlocillin sodium）, on this basis, the observation group was given budesonide suspension, the control group was given chloramphenicol ear drops. At the end of treatment, the treatment effect of the two groups was compared. Results Compared with the control group, the improvement of hearing in the observation group was significanfly improved （ x2 = 21.05, P 〈 0.01 ）, the rate of tympanic effusion was significantly lower （ t = 15.30, P 〈 0.01 ）, and the effective decrease rate of tympanic cavity pressure was significantly higher （ t = 10.61, P 〈 0. 01 ）. The clinical symptom score of the observation group was significantly reduced, and the degree of improvement was much better than that of the control group （ t = 16.99 ,P 〈 0.01 ）. The onset time and hospitalization time of the observation group were significantly shortened ,and the differences were statistically significant （t = 13.37,13.89, all P 〈 0.01 ）. The total effective rate of the observation group was 95.3% ,which of the control group was 78.9% ,and there was statistically significant difference between the two groups （ x2 = 20.19 ,P 〈 0.01 ）. The incidence rate of adverse reactions in the observation group was significantly lower than that in the control group, the difference was statistically significant （ x2 = 8.07,P 〈 0.05 ）. Conclusion Budesonide suspension combined with antibiotics in the treatment of children with acute otitis media has significant effect, it is conducive to reduce the formation of tympanic effusion, improve ehildren＇s hearing and treatment effect, and worthy of further clinical application.