盐酸氨溴索雾化吸入联合红霉素对新生儿肺炎患儿高敏C反应蛋白、心肌酶水平及临床疗效的影响

Effect of atomization inhalation of ambroxol hydrochloride combined with erythromycin on high sensitivity C reactive protein, myocardial enzyme level in neonatal pneumonia patients

目的 探讨盐酸氨溴索雾化吸入联合红霉素对新生儿肺炎患儿高敏C反应蛋白（hc-CRP）、心肌酶水平及临床疗效的影响.方法 收集100例新生儿肺炎患儿,采用随机数字表法将其分为观察组和对照组,每组50例.对照组给予红霉素30 mg/kg,1次/d;观察组则在对照组基础上给予盐酸氨溴索雾化吸入,15 min/次,3次/d.均连续治疗4周.治疗结束后对两组临床症状消失时间、hs-CRP水平、CK-MB水平以及临床疗效进行比较.结果 与治疗前相比,治疗后两组hs-CRP、人肌酸激酶同工酶（CK-MB）水平均下降;治疗后,与对照组相比,观察组hs-CRP[（7.25±2.11）mg/L比（12.21±3.76）mg/L]、CK-MB[（21.31±4.42）U/L比（27.12±3.17）U/L]水平均较低,差异均有统计学意义（t=8.134、7.553,均P〈0.05）,临床症状消失时间均缩短,差异均有统计学意义（t=6.520、11.824、19.473,均P〈0.05）,临床疗效较好.结论 盐酸氨溴索雾化吸入联合红霉素能够降低新生儿肺炎患儿hs-CRP、CK-MB水平,缩短临床症状消失时间,疗效较好,对临床有指导意义.

Objective To investigate the effect of ambroxol atomization inhalation combined with erythromycin on neonatal pneumonia patients and its influence on high sensitivity C reactive protein（ hs-CRP） ,myocardial enzyme level. Methods 100 cases of neonatal pneumonia were selected and they were randomly divided into observation group and control group according to the digital table,50 cases in each group. The control group was treated with erythromycin 30mg/kg, 1 time/d. The observation group was given ambroxol ultrasonic nebulizer inhalation, 15 minutes per time,3 times daily,on the basis of the treatment of the control group. The patients were treated for 4 consecutive weeks. The clinical symptoms disappeared time, hs -CRP level, CK -MB level and clinical efficacy were detected and compared. Results Compared with before treatment, the hs - CRP and CK - MB levels were decreased after treatment. Compared with the control group,the hs - CRP[（7. 25 ± 2. 11） mg/L vs. （12. 21 ± 3. 76）mg/L] and CK-MB[（21. 31 ± 4. 42） U/L vs. （27. 12 ± 3. 17） U/L] levels in the observation group were lower（t=8. 134,7. 553,all P〈0. 05）,the clinical symptoms disappeared in a relatively shorter time（t= 6. 520, 11. 824,19. 473,all P〈0. 05）,the clinical curative effect was better. Conclusion Ambroxol aerosol inhalation combined with erythromycin can reduce hs-CRP,CK-MB levels in neonatal pneumonia patients,and the clinical symptoms of the patients disappeared in a relatively short time, the clinical curative effect is better, has guiding significance in clinic.