火棘对高脂饮食大鼠血脂和血液流变学影响

Effects of Pyracantha on Plasma Lipid and Blood Rheology of Rats Fed a High Fat Diet

目的 探讨火棘对心血管疾病的预防和保健作用。方法 将Wistar大鼠随机分为 4组 ,分别喂以标准饲料、标准饲料中添加 15 %的火棘果实粉、高脂饲料、高脂饲料中添加 15 %的火棘果实粉。 10周后测定血浆总胆固醇TC、甘油三酯TG、高密度脂蛋白胆固醇HDL -C、低密度脂蛋白胆固醇LDL -C、载脂蛋白apoA、apoB、全血比粘度、血浆比粘度、红细胞压积 ,计算纤维蛋白原粘度、红细胞聚集指数 ,并测定心肌酶的活性。结果 火棘组和火棘高脂组HDL -C、apoA水平明显高于正常对照组和高脂组 ,apoB/apoA比值明显低于对照组 ,火棘能显著降低高脂饮食动物TG、TC、全血比粘度、血浆比粘度、纤维蛋白原比粘度、红细胞聚集指数以及心肌酶活性。结论 火棘能降低高脂饮食大鼠血脂 ,改善脂蛋白代谢和高脂饮食大鼠的血流状态 ,保护心肌 。

Objective To study the preventive and health effects of pyracantha on cardiovascular disease.Methods Four groups of Wistar rats were fed respectively with standard diet,85% standard diet plus 15% pyracantha ,high fat diet,85% high fat diet plus 15% pyracantha .Ten weeks later,the Plasma TC,TG,HDL-C,LDL-C,apoA,apoB.whole blood viscosity,plasma viscosity,and hematorcrit were determinated while plasma fibrinogen and inhibited erythrocyte aggregation were calculated,and serum creatine kinase (CK),creatine kinase isoenzyme MB(CK-MB),lactic dehydrogenase(LDH),and α-hydroxybutyric acid dehydrogenase(HBDB) were measured too.Results At the end of the experiment,the plasma HDL-C and apoA levels of pyracantha groups were significantly higher than that of control groups,while the ratios of apoB/apoA were significantly lower than that of control groups. Pyracantha decreased TC,TG,the whole blood viscosity,plasma viscosity,plasma fibrinogen,inhibited erythrocyte aggregation and the activities of myocardial enzymes.Conclusion Pyracantha could significantly improve the lipoprotein metabolism and the hermorrheology,decreased blood lipids of rats fed with high fat diet,and protected myocardial cell.There were preventive and health effects of pyracantha on cardiovascular disease.