肝脏疾病与甲状腺功能状态

Liver diseases and thyroid functional status

许多肝脏疾病会出现甲状腺功能异常,引起肝炎的乙型肝炎病毒(hepatitis B virus,HBV)和丙型肝炎病毒(hepatitis C virus,HCV)感染及肝炎本身可以出现甲状腺功能异常,抗HBV、HCV治疗的干扰素α引起甲状腺功能异常也很常见.肝硬化、非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)可以出现甲状腺功能异常,但是NAFLD与甲状腺功能异常的因果关系未阐明.同时,甲状腺疾病如甲状腺功能亢进(甲亢)、甲状腺功能减退(甲减)也可以出现肝功能异常.抗甲状腺药物(antithyroid drugs,ATD)和超常规剂量左旋甲状腺素均可导致肝损害,但以ATD更多见.

The liver is closely related to the thyroid function. On one hand, many liver diseases can cause abnormal thyroid function, such as hepatitis B virus（HBV） infection, hepatitis C virus（HCV） infection, liver cirrhosis, and nonalcohol ic fatty liver disease. Thyroid dysfunction is also commonly caused by interferon alpha treatment for anti-HBV or HCV therapy. On the other hand, thyroid diseases such as hyperthyroidism or hypothyroidism can result in abnormal liver function. In addition,liver injury can also be frequently caused by antithyroid drugs or levothyroxine of over conventional doses. The causal relationship between abnormal liver function and thyroid dysfunction remains unclear.